{"id":18,"date":"2020-08-28T04:59:28","date_gmt":"2020-08-28T02:59:28","guid":{"rendered":"http:\/\/montagnelab.com\/?page_id=18"},"modified":"2026-10-25T18:03:40","modified_gmt":"2026-10-25T17:03:40","slug":"mesmerize","status":"publish","type":"page","link":"https:\/\/montagnelab.com\/","title":{"rendered":"Home"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"18\" class=\"elementor elementor-18\">\n\t\t\t\t<div class=\"elementor-element elementor-element-50af841c e-flex e-con-boxed e-con e-parent\" data-id=\"50af841c\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-41dde37e elementor-widget elementor-widget-text-editor\" data-id=\"41dde37e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t\n<p class=\"wp-block-paragraph\">The brain relies on an extensive network of blood vessels to deliver oxygen and nutrients, maintain a healthy environment, and support normal brain function. At the heart of this system is the <span style=\"color: #ad0c00;\"><strong>blood-brain barrier (BBB)<\/strong><\/span>, a specialised interface that protects the brain and regulates exchanges between the blood and brain tissue. Increasing evidence suggests that dysfunction of the brain&#8217;s blood vessels and BBB is an early and important contributor to <span style=\"color: #ad0c00;\"><strong>ageing<\/strong><\/span>, <span style=\"color: #ad0c00;\"><strong>cognitive decline<\/strong><\/span>, and <span style=\"color: #ad0c00;\"><strong>dementia<\/strong><\/span>.<\/p>\n<p>At the <strong><span style=\"color: #ad0c00;\">Montagne Lab<\/span><\/strong>, we investigate how the cells that make up the brain&#8217;s smallest blood vessels, particularly <span style=\"color: #ad0c00;\"><strong>endothelial cells<\/strong><\/span> and <strong><span style=\"color: #ad0c00;\">pericytes<\/span><\/strong>, become dysfunctional during ageing and disease. We aim to understand how changes in these cells and their interactions contribute to BBB breakdown, impaired cerebral blood flow, vascular inflammation, and damage to the brain&#8217;s white matter.<\/p>\n<p>By combining advanced <strong><span style=\"color: #ad0c00;\">brain imaging<\/span><\/strong>, <strong><span style=\"color: #ad0c00;\">experimental models<\/span><\/strong>, <strong><span style=\"color: #ad0c00;\">human brain tissue<\/span><\/strong>, and <strong><span style=\"color: #ad0c00;\">cutting-edge molecular approaches<\/span><\/strong>, we seek to uncover the mechanisms driving neurovascular dysfunction in Alzheimer&#8217;s disease, cerebral Small Vessel Disease, and related dementias. Our ultimate goal is to identify new therapeutic strategies that restore vascular health and protect brain function.<\/p>\n\n<figure class=\"wp-block-image aligncenter size-large\"><img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"815\" class=\"wp-image-1131\" src=\"https:\/\/montagnelab.com\/wp-content\/uploads\/2022\/09\/Lab-collage-v2-1024x815.png\" alt=\"\" srcset=\"https:\/\/montagnelab.com\/wp-content\/uploads\/2022\/09\/Lab-collage-v2-1024x815.png 1024w, https:\/\/montagnelab.com\/wp-content\/uploads\/2022\/09\/Lab-collage-v2-300x239.png 300w, https:\/\/montagnelab.com\/wp-content\/uploads\/2022\/09\/Lab-collage-v2-768x611.png 768w, https:\/\/montagnelab.com\/wp-content\/uploads\/2022\/09\/Lab-collage-v2-1536x1222.png 1536w, https:\/\/montagnelab.com\/wp-content\/uploads\/2022\/09\/Lab-collage-v2-1140x907.png 1140w, https:\/\/montagnelab.com\/wp-content\/uploads\/2022\/09\/Lab-collage-v2.png 1805w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n<blockquote class=\"is-layout-flow wp-block-quote-is-layout-flow\">\n<p>Our research aims to understand how, when, and why the brain&#8217;s blood vessels become dysfunctional during ageing and dementia. By studying the interactions between endothelial cells, pericytes, and their surrounding environment, we hope to identify new ways to preserve the blood-brain barrier, maintain healthy cerebral blood flow, and ultimately prevent cognitive decline.<\/p>\n<\/blockquote>\n<p>\u00a0<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>The brain relies on an extensive network of blood vessels to deliver oxygen and nutrients, maintain a healthy environment, and [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-18","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/montagnelab.com\/index.php?rest_route=\/wp\/v2\/pages\/18","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/montagnelab.com\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/montagnelab.com\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/montagnelab.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/montagnelab.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=18"}],"version-history":[{"count":42,"href":"https:\/\/montagnelab.com\/index.php?rest_route=\/wp\/v2\/pages\/18\/revisions"}],"predecessor-version":[{"id":2218,"href":"https:\/\/montagnelab.com\/index.php?rest_route=\/wp\/v2\/pages\/18\/revisions\/2218"}],"wp:attachment":[{"href":"https:\/\/montagnelab.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=18"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}